Synthesis of maculalactone A and derivatives for environmental fate tracking studies.
نویسندگان
چکیده
Maculalactone A (1) constitutes a promising antifouling agent, inhibiting the formation of biofilms in marine and freshwater systems. In this study, we developed a new route, based on a late-stage formation of the butenolide core, leading to the total synthesis of maculalactone A (three steps, overall yield of 45%) and delivering material on a gram scale. In addition, analogues of the title compound were assayed concerning their biological activity, utilizing Artemia franciscana and Thamnocephalus platyurus. The most active analogue was functionalized with a rhodamine B fluorophore and was utilized in an in vivo staining experiment in Artemia salina. Two different tissues were found to accumulate this maculalactone A derivative.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 1 شماره
صفحات -
تاریخ انتشار 2015